Protykin® (Polygonum cuspidatum root) is a patented high potency 200:1 standardized Polygonum cuspidatum extract, supplying antioxidant benefits. Derived from the root of Polygonum cuspidatum, Protykin® may help support healthy aging. Protykin® has gone through a number of clinical studies and has been shown to be effective against H.pylori infections often associated with stomach ulcers. Other studies have indicated that Protykin® can have heart-protective qualities, particularly in women. The main ingredient in Protykin has also been shown to be a potent antioxidant, anti-inflammatory, and has anti-cancer activity. It appears to be a more potent anti-inflammatory than non-steroidal anti-inflammatory drug (NSAIDs) such as Aspirin, Ibuprofen, or Indomethacin. In animal studies, its main ingredient has been shown to kill off ovarian and breast cancer cells. It has also been shown to be a phytoestrogen and to have other potential benefits for cardiovascular health by lowering certain blood lipids (fats).

Black Cohosh (Cimicifuga Racemosa) has been used in traditional medicine to treat the hot flashes of menopause. A number of clinical studies have indicated that Black Cohosh, particularly in combination with other herbs, is also effective in minimizing the psychological symptoms as well. Black Cohosh is not a phytoestrogen but has estrogen-like effects. The improvement in psychological symptoms may be due to the effects on 5-HTP receptors.

DIM (Diindolylmethane) is the active metabolite of indole-3-carbinol, a component of cruciferous vegetables such as cabbage, broccoli, cauliflower and Brussels sprouts. Evidence suggests that DIM is the active cancer-protective agent in these cruciferous vegetables. DIM has both estrogen agonist and antagonist properties.

Rhodiola Rosea has traditionally been used as an adaptogen- a term used to describe herbs that aid in re-balancing the body and adapting to stress. Rhodiola has been used to maintain strength, stamina and cognitive abilities, including improving memory and concentration. Rhodiola, also known as roseroot, has also been shown to have protective effects on the heart, help control diabetes, aid and safeguard liver function and to minimize and prevent fatigue after stress.

Boron (Citrate) is a trace mineral thought to be important in bone health, in preventing and treating osteoarthritis and osteoporosis. Boron is also believed to play an important role in reproduction and development. Boron has been noted to increase estradiol levels in postmenopausal women who are taking estrogen replacements. There is also preliminary evidence that Boron supplementation may improve cognitive function. Other evidence indicates that Boron may help alleviate menopausal symptoms such as difficulties in concentration and short-term memory.

Tocopherol Acetate (Vitamin E) is one of the most important natural antioxidants. Antioxidants such as vitamin E prevent the damage caused by free radicals that are produced as natural by-products of biochemical reactions. If left unchecked, these free radicals cause damage to cells and tissues and can cause inflammation. For women's health, vitamin E has been shown to be important in treating menstrual problems such as PMS and the hot flashes often also associated with menopause. The North American Menopause Society has recommended the use of vitamin E for treating hot flashes. Other studies on heart health have shown that vitamin E may be very important in maintaining cardiovascular health. There is also scientific interest in vitamin E as a cancer preventive agent and as an important factor in the health of the nervous system. Vitamin E has also been found to boost certain arms of the immune system.

Zinc (Amino Acid Chelate) is an essential trace metal and plays an important role in the structure of cells and proteins and in a healthy immune system. Zinc seems to play a particularly important role as an antiviral substance. Zinc is absolutely required in a number of important enzyme reactions, particularly in antioxidant reactions. Zinc also plays an important role in regulating gene expression and cell signaling.

Chasteberry (Vitex agnus-castus) has been used for centuries in Europe and Northern Africa to balance a woman's hormonal systems. The active substances are primarily the essentials oils and flavonoids. These substances help regulate the female hormonal system and some of the symptoms associated with perimenopause and PMS. Chasteberry does this by acting to suppress some hormones such as prolactin and mimicking other hormones such as estrogen and progesterone. Overall, Chasteberry acts to normalize the luteal phase of the menstrual cycle—the phase right before menstrual flow. Clinical studies using Chasteberry have shown it to be effective in relieving a number of symptoms common in perimenopause including breast tenderness, swelling, depression, irritability and insomnia.

Red Clover has a long history of use in relieving menopausal symptoms—and appears to be particularly useful in relieving the anxiety and depression that are so often associated with perimenopause and menopause. Red Clover has also been shown to be effective in a number of clinical studies in relieving hot flashes, breast tenderness, mood swings and night sweats. Red Clover contains substances that are metabolized in the body to genistein and daidzein, components found in soy products. These are believed to be responsible for decreasing hot flashes, reducing total cholesterol and blood lipid levels, and possibly protecting a woman's bones against osteoporosis.

Soy Isoflavones are phytoestrogens and act to reduce hot flashes.The isoflavones are also effective in lowering cholesterol, controlling diabetes and reducing the chances of osteoporosis.

Passion Flower (Passiflora) has been used as an anti-anxiety agent, an anti-depressant and a sleep-inducing agent.

Soy Lignans are a type of phytoestrogen that have been used to treat menopausal symptoms of hot flashes and night sweats. Lignans have also been shown effective in controlling diabetes and its associated inflammatory effects.

Wild Yam contains diosgenin, a steroid precursor that has properties similar to estrogen and progesterone. Wild Yam has been used traditionally to treat postmenopausal vaginal dryness, hot flashes and hot flushes, infertility, osteoporosis and to increase energy levels and libido in both men and women. It has also been used to treat menstrual cramping and PMS. Post-menopausal women taking Wild Yam products have increased serum estrone, estradiol and sex hormone binding globulin. No significant side effects have been noted. Because Wild Yam may have estrogenic properties, women with a history of estrogen-sensitive breast cancers are cautioned to speak with their healthcare professional before using Wild Yam products.

Melatonin is nature's "sleep hormone". It controls the normal sleep-wake cycle. It has been reported to help reduce the time to fall asleep and affect how long you stay asleep. Also, Melatonin has been found to be directly effective in reducing thyroid problems and changes in the female reproductive hormones in menopausal women.

Hesperidin (Methyl Chalcone) is a bioflavonoid derived from citrus fruit and is an antioxidant and an anti-inflammatory agent. Hesperidin also works to strengthen the blood vessels.

Passion Flower (Passiflora) has been used as an anti-anxiety agent, an anti-depressant and a sleep-inducing agent.

5-HTP (Griffonia simplicifolia) Seed Extract is used to aid in sleep and combat feelings of depression. 5HTP has sedative properties; it should not be used with alcohol or any other sedatives unless under the care of a qualified healthcare professional.

Ammonium Succinate is an Ammonium salt of Succinate. Animal studies and a small clinical study have indicated that ammonium succinate as the most concentrated ingredient effective in reducing symptoms of menopause including hot flashes, anxiety and headaches. Estradiol concentrations were increased in a number of women. Other studies from the same group also indicated positive responses, particularly in early perimenopause.

Potassium (as Potassium Citrate) is potassium the salt of citric acid. There have been some studies that indicated that potassium was effective in reducing symptoms of menopause. Some of the symptoms included hot flashes, anxiety and headaches. Estradiol concentrations were reported to increase in a number of women. Other studies from the same group also indicated positive response, particularly in early perimenopause.

Valerian Root is a sedative and an anti-anxiety agent and is very effective in helping overcome insomnia and reducing the amount of time it takes to fall asleep. As Valerian has sedative properties, it should not be used with alcohol or any other sedatives unless under the care of a qualified healthcare professional.

Calcium helps to prevent bone loss and osteoporosis and is useful for alleviating a depressed mood as well.

Magnesium (as Magnesium Oxide) is the most common positive ion in the body and is helpful for bones, nerves, muscles and is an important part of many reactions in the body. It is helpful in inducing restful sleep. Magnesium has also been used to reduce the mood changes associated with menopause, PMS and the headaches often associated with both.

Glycine is an amino acid—one of the protein "building blocks". It is believed to be particularly important in improving memory and clear thinking. It binds to certain brain receptors thought to be part of the memory and learning process. Glycine also acts to lower blood pressure naturally and to protect the liver. Glycine may also be important in restoring the antioxidant glutathione, particularly in women with pre-diabetes, diabetes and metabolic syndrome.